{"id":1098,"date":"2025-10-16T21:07:48","date_gmt":"2025-10-16T19:07:48","guid":{"rendered":"https:\/\/emanuelabottanilab.it\/attivita-di-ricerca\/"},"modified":"2025-11-27T17:17:10","modified_gmt":"2025-11-27T16:17:10","slug":"research-activities","status":"publish","type":"page","link":"https:\/\/emanuelabottanilab.it\/en\/research-activities\/","title":{"rendered":"Research Activities\u00a0"},"content":{"rendered":"\n<div class=\"wp-block-greenshift-blocks-row alignfull gspb_row gspb_row-id-gsbp-84347f7 gspb_row--gutter-custom-0\" id=\"gspb_row-id-gsbp-84347f7\"><div class=\"gspb_row__content\"> \n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--6 gspb_row__col--md-12 gspb_col-id-gsbp-55c4c03\" id=\"gspb_col-id-gsbp-55c4c03\">\n<div class=\"wp-block-greenshift-blocks-container gspb_container gspb_container-gsbp-b93ed40\" id=\"gspb_container-id-gsbp-b93ed40\">\n<div class=\"wp-block-greenshift-blocks-container gspb_container gspb_container-gsbp-caa6797\" id=\"gspb_container-id-gsbp-caa6797\">\n<div class=\"wp-block-greenshift-blocks-image gspb_image gspb_image-id-gsbp-d7b7e4d\" id=\"gspb_image-id-gsbp-d7b7e4d\"><img decoding=\"async\" src=\"https:\/\/emanuelabottanilab.it\/cms\/wp-content\/uploads\/2025\/10\/210_210.jpg\" data-src=\"\" alt=\"\" loading=\"lazy\" width=\"100%\" height=\"210\"\/><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-container gspb_container gspb_container-gsbp-3102b55\" id=\"gspb_container-id-gsbp-3102b55\">\n<div class=\"wp-block-greenshift-blocks-image gspb_image gspb_image-id-gsbp-dfee401\" id=\"gspb_image-id-gsbp-dfee401\"><img decoding=\"async\" src=\"https:\/\/emanuelabottanilab.it\/cms\/wp-content\/uploads\/2025\/10\/390_330.jpg\" data-src=\"\" alt=\"\" loading=\"lazy\" width=\"100%\" height=\"330\"\/><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-container gspb_container gspb_container-gsbp-51f2e6c\" id=\"gspb_container-id-gsbp-51f2e6c\">\n<div class=\"wp-block-greenshift-blocks-image gspb_image gspb_image-id-gsbp-550390a\" id=\"gspb_image-id-gsbp-550390a\"><img decoding=\"async\" src=\"https:\/\/emanuelabottanilab.it\/cms\/wp-content\/uploads\/2025\/10\/290_290.jpg\" data-src=\"\" alt=\"\" loading=\"lazy\" width=\"100%\" height=\"290\"\/><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-container gspb_container gspb_container-gsbp-bde1c51\" id=\"gspb_container-id-gsbp-bde1c51\">\n<div class=\"wp-block-greenshift-blocks-image gspb_image gspb_image-id-gsbp-ddb9114\" id=\"gspb_image-id-gsbp-ddb9114\"><img decoding=\"async\" src=\"https:\/\/emanuelabottanilab.it\/cms\/wp-content\/uploads\/2025\/10\/230_230.jpg\" data-src=\"\" alt=\"\" loading=\"lazy\" width=\"100%\" height=\"230\"\/><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--6 gspb_row__col--md-12 gspb_col-id-gsbp-502657b\" id=\"gspb_col-id-gsbp-502657b\">\n<h2 id=\"gspb_heading-id-gspb-UdG4q3VW8rfFITty4mInj\" class=\"gspb_heading gspb_heading-id-gspb-UdG4q3VW8rfFITty4mInj \">Research Activities<br>Emanuela Bottani Lab<\/h2>\n\n\n\n<p id=\"gspb_text-id-gsbp-40b318f\" class=\"gspb_text gspb_text-id-gsbp-40b318f gs_opacity_75\">Our laboratory is dedicated to the study of genetic diseases involving mitochondrial and metabolic dysfunction.<br>Although individually rare, these conditions rank among the most severe pediatric disorders, often associated with profound neurological impairment and a lack of effective therapeutic options.<br>Taken together, they represent a significant burden for affected families and a major challenge for contemporary medicine.<\/p>\n<style>.gs_opacity_75{opacity:0.75}<\/style>\n\n\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-1bb6df5\" id=\"mito-gen-lab\" data-block-id=\"1bb6df5\"><style>.stk-1bb6df5 {margin-top:var(--stk--preset--spacing--50, 1.5rem) !important;margin-bottom:50px !important;}.stk-1bb6df5 .stk-inner-blocks{column-gap:36px !important;}@media screen and (max-width:689px){.stk-1bb6df5 {margin-bottom:0px !important;}}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-button stk-block-button stk-block stk-49d581f\" data-block-id=\"49d581f\"><style>.stk-49d581f .stk-button{padding-top:12px !important;padding-right:40px !important;padding-bottom:12px !important;padding-left:40px !important;border-top-left-radius:50px !important;border-top-right-radius:50px !important;border-bottom-right-radius:50px !important;border-bottom-left-radius:50px !important;}.stk-49d581f .stk-button__inner-text{font-size:1.15em !important;}@media screen and (max-width:999px){.stk-49d581f .stk-button__inner-text{font-size:1.15em !important;}}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/emanuelabottanilab.it\/en\/who-we-are\/\"><span class=\"stk-button__inner-text\">WHO WE ARE<\/span><\/a><\/div>\n\n\n\n<div class=\"wp-block-stackable-button stk-block-button is-style-ghost stk-block stk-162e480\" data-block-id=\"162e480\"><style>.stk-162e480 .stk-button{padding-top:12px !important;padding-right:40px !important;padding-bottom:12px !important;padding-left:40px !important;background:transparent !important;border-top-left-radius:50px !important;border-top-right-radius:50px !important;border-bottom-right-radius:50px !important;border-bottom-left-radius:50px !important;}:where(.stk-hover-parent:hover,  .stk-hover-parent.stk--is-hovered) .stk-162e480 .stk-button:after{background:transparent !important;opacity:1 !important;}.stk-162e480 .stk-button:before{border-style:solid !important;border-top-width:2px !important;border-right-width:2px !important;border-bottom-width:2px !important;border-left-width:2px !important;}.stk-162e480 .stk-button__inner-text{font-size:1.2em !important;color:var(--theme-palette-color-1, #779393) !important;}.stk-162e480 .stk-button:hover .stk-button__inner-text{color:var(--theme-palette-color-2, #4b7878) !important;}@media screen and (max-width:999px){.stk-162e480 .stk-button__inner-text{font-size:1.2em !important;}}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/emanuelabottanilab.it\/en\/pubblications\/\"><span class=\"has-text-color has-palette-color-1-color stk-button__inner-text\">PUBLICATIONS<\/span><\/a><\/div>\n<\/div><\/div>\n<\/div>\n <\/div><\/div>\n\n\n\n<section class=\"gsbp-fd63c50 alignfull\" id=\"missione\">\n<div class=\"gsbp-650953a\">\n<div class=\"service-card\">\n<div class=\"service-card__content gsbp-eb5b935\">\n<h4 class=\"service-card__heading\">New perspectives<\/h4>\n\n\n\n<p class=\"service-card__blurb\">Our research aims to understand how mitochondrial dysfunction contributes to altered brain development.<br>Although many mitochondrial diseases have long been regarded primarily as neurodegenerative conditions, recent evidence suggests that they also involve a significant alteration of neurodevelopment.<br>By investigating how metabolic imbalance and bioenergetic deficiency affect the early stages of neuronal maturation, we aim to open new perspectives for the development of therapeutic strategies.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"service-card\">\n<div class=\"service-card__content gsbp-ed41747\">\n<h4 class=\"service-card__heading\">Identification<\/h4>\n\n\n\n<p class=\"service-card__blurb\">To address these questions, we employ a multidisciplinary approach that integrates innovative preclinical models, 2D and 3D cellular models, and genetically modified animal models, including mice and pigs, to investigate disease mechanisms at various levels of complexity.<br>This strategy enables us to assess the impact of mitochondrial dysfunction on neurodevelopment and identify potential pathways that could serve as targets for therapeutic intervention.<br>A central goal of our work is to translate mechanistic insights into therapeutic opportunities.\u00a0<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"service-card\">\n<div class=\"service-card__content gsbp-bb6ee30\">\n<h4 class=\"service-card__heading\">Therapeutic developments<\/h4>\n\n\n\n<p class=\"service-card__blurb\">We explore strategies including drug repurposing, pharmacological modulation of mitochondrial metabolism, and gene therapy approaches.<br>Through this work, we aim to build a solid preclinical foundation to support future clinical studies.<br>Our research is part of a network of collaborations with international research groups and patient associations, ensuring that our studies remain closely aligned with the needs of patients and their families.\u00a0<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"_gspb_post_css":"#gspb_row-id-gsbp-84347f7{justify-content:space-between;margin-top:0;display:flex;flex-wrap:wrap;align-content:center;margin-bottom:64px;padding:2rem}#gspb_row-id-gsbp-84347f7>.gspb_row__content{display:flex;justify-content:space-between;margin:0 auto;width:100%;row-gap:3rem;flex-wrap:wrap;max-width:1280px;align-items:center}.gspb_row{position:relative}div[id^=gspb_col-id]{box-sizing:border-box;position:relative;padding:var(--gs-row-column-padding, 15px min(3vw, 20px))}@media (max-width:767.98px){#gspb_row-id-gsbp-84347f7{padding-right:1rem;padding-left:1rem}}#gspb_col-id-gsbp-55c4c03.gspb_row__col--6{width:calc(50% - 1.5rem)}@media 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