{"id":1105,"date":"2025-01-01T00:00:00","date_gmt":"2024-12-31T23:00:00","guid":{"rendered":"https:\/\/emanuelabottanilab.it\/?post_type=pubblicazioni&#038;p=1105"},"modified":"2025-11-10T10:56:21","modified_gmt":"2025-11-10T09:56:21","slug":"pluripotent-stem-cell-based-drug-discovery-uncovers-sildenafil-as-a-treatment-for-mitochondrial-disease","status":"publish","type":"pubblicazioni","link":"https:\/\/emanuelabottanilab.it\/en\/pubblicazioni\/pluripotent-stem-cell-based-drug-discovery-uncovers-sildenafil-as-a-treatment-for-mitochondrial-disease\/","title":{"rendered":"Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease"},"template":"","meta":{"_gspb_post_css":""},"class_list":["post-1105","pubblicazioni","type-pubblicazioni","status-publish","hentry"],"blocksy_meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease - Emanuela Bottani Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/emanuelabottanilab.it\/en\/pubblicazioni\/pluripotent-stem-cell-based-drug-discovery-uncovers-sildenafil-as-a-treatment-for-mitochondrial-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease - Emanuela Bottani Lab\" \/>\n<meta property=\"og:url\" content=\"https:\/\/emanuelabottanilab.it\/en\/pubblicazioni\/pluripotent-stem-cell-based-drug-discovery-uncovers-sildenafil-as-a-treatment-for-mitochondrial-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Emanuela Bottani Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-10T09:56:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/emanuelabottanilab.it\/cms\/wp-content\/uploads\/2025\/09\/logo_mitogen_dark-scaled.png\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"991\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/emanuelabottanilab.it\\\/en\\\/pubblicazioni\\\/pluripotent-stem-cell-based-drug-discovery-uncovers-sildenafil-as-a-treatment-for-mitochondrial-disease\\\/\",\"url\":\"https:\\\/\\\/emanuelabottanilab.it\\\/en\\\/pubblicazioni\\\/pluripotent-stem-cell-based-drug-discovery-uncovers-sildenafil-as-a-treatment-for-mitochondrial-disease\\\/\",\"name\":\"Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease - Emanuela Bottani Lab\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/emanuelabottanilab.it\\\/en\\\/#website\"},\"datePublished\":\"2024-12-31T23:00:00+00:00\",\"dateModified\":\"2025-11-10T09:56:21+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/emanuelabottanilab.it\\\/en\\\/pubblicazioni\\\/pluripotent-stem-cell-based-drug-discovery-uncovers-sildenafil-as-a-treatment-for-mitochondrial-disease\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/emanuelabottanilab.it\\\/en\\\/pubblicazioni\\\/pluripotent-stem-cell-based-drug-discovery-uncovers-sildenafil-as-a-treatment-for-mitochondrial-disease\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/emanuelabottanilab.it\\\/en\\\/pubblicazioni\\\/pluripotent-stem-cell-based-drug-discovery-uncovers-sildenafil-as-a-treatment-for-mitochondrial-disease\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/emanuelabottanilab.it\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/emanuelabottanilab.it\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/emanuelabottanilab.it\\\/en\\\/\",\"name\":\"Emanuela Bottani Lab\",\"description\":\"FUELING THE FUTURE OF RARE DISEASE CARE\",\"publisher\":{\"@id\":\"https:\\\/\\\/emanuelabottanilab.it\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/emanuelabottanilab.it\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/emanuelabottanilab.it\\\/en\\\/#organization\",\"name\":\"Emanuela Bottani Lab\",\"url\":\"https:\\\/\\\/emanuelabottanilab.it\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/emanuelabottanilab.it\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/emanuelabottanilab.it\\\/cms\\\/wp-content\\\/uploads\\\/2025\\\/09\\\/logo_mitogen_dark-scaled.png\",\"contentUrl\":\"https:\\\/\\\/emanuelabottanilab.it\\\/cms\\\/wp-content\\\/uploads\\\/2025\\\/09\\\/logo_mitogen_dark-scaled.png\",\"width\":2560,\"height\":991,\"caption\":\"Emanuela Bottani Lab\"},\"image\":{\"@id\":\"https:\\\/\\\/emanuelabottanilab.it\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease - Emanuela Bottani Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/emanuelabottanilab.it\/en\/pubblicazioni\/pluripotent-stem-cell-based-drug-discovery-uncovers-sildenafil-as-a-treatment-for-mitochondrial-disease\/","og_locale":"en_US","og_type":"article","og_title":"Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease - Emanuela Bottani Lab","og_url":"https:\/\/emanuelabottanilab.it\/en\/pubblicazioni\/pluripotent-stem-cell-based-drug-discovery-uncovers-sildenafil-as-a-treatment-for-mitochondrial-disease\/","og_site_name":"Emanuela Bottani Lab","article_modified_time":"2025-11-10T09:56:21+00:00","og_image":[{"width":2560,"height":991,"url":"https:\/\/emanuelabottanilab.it\/cms\/wp-content\/uploads\/2025\/09\/logo_mitogen_dark-scaled.png","type":"image\/png"}],"twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/emanuelabottanilab.it\/en\/pubblicazioni\/pluripotent-stem-cell-based-drug-discovery-uncovers-sildenafil-as-a-treatment-for-mitochondrial-disease\/","url":"https:\/\/emanuelabottanilab.it\/en\/pubblicazioni\/pluripotent-stem-cell-based-drug-discovery-uncovers-sildenafil-as-a-treatment-for-mitochondrial-disease\/","name":"Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease - Emanuela Bottani Lab","isPartOf":{"@id":"https:\/\/emanuelabottanilab.it\/en\/#website"},"datePublished":"2024-12-31T23:00:00+00:00","dateModified":"2025-11-10T09:56:21+00:00","breadcrumb":{"@id":"https:\/\/emanuelabottanilab.it\/en\/pubblicazioni\/pluripotent-stem-cell-based-drug-discovery-uncovers-sildenafil-as-a-treatment-for-mitochondrial-disease\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/emanuelabottanilab.it\/en\/pubblicazioni\/pluripotent-stem-cell-based-drug-discovery-uncovers-sildenafil-as-a-treatment-for-mitochondrial-disease\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/emanuelabottanilab.it\/en\/pubblicazioni\/pluripotent-stem-cell-based-drug-discovery-uncovers-sildenafil-as-a-treatment-for-mitochondrial-disease\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/emanuelabottanilab.it\/en\/"},{"@type":"ListItem","position":2,"name":"Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease"}]},{"@type":"WebSite","@id":"https:\/\/emanuelabottanilab.it\/en\/#website","url":"https:\/\/emanuelabottanilab.it\/en\/","name":"Emanuela Bottani Lab","description":"FUELING THE FUTURE OF RARE DISEASE CARE","publisher":{"@id":"https:\/\/emanuelabottanilab.it\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/emanuelabottanilab.it\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/emanuelabottanilab.it\/en\/#organization","name":"Emanuela Bottani Lab","url":"https:\/\/emanuelabottanilab.it\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/emanuelabottanilab.it\/en\/#\/schema\/logo\/image\/","url":"https:\/\/emanuelabottanilab.it\/cms\/wp-content\/uploads\/2025\/09\/logo_mitogen_dark-scaled.png","contentUrl":"https:\/\/emanuelabottanilab.it\/cms\/wp-content\/uploads\/2025\/09\/logo_mitogen_dark-scaled.png","width":2560,"height":991,"caption":"Emanuela Bottani Lab"},"image":{"@id":"https:\/\/emanuelabottanilab.it\/en\/#\/schema\/logo\/image\/"}}]}},"meta_box":{"descrizione_pubblicazione":" Annika Zink, DaoFu Dai, Annika Wittich, Marie-Th\u00e9r\u00e8se Henke, Giulia Pedrotti, Sonja Heiduschka, Guillem S. Aguilar, Tancredi Massimo Pentimalli, Christian Brueser, Sofia Notopoulou, Aleksandra Zhaivoron, Abdul Rahim Umar, Laura Petersilie, Caleb Jerred, Jesper Bergmans, Fabian Schumacher, Jan Keller-Findeisen, Agnieszka Rybak-Wolf, Daniel Stach, Jeanette Reinshagen, Andrea Zaliani, Undine Haferkamp, Liliya Euro, Alessia Di Donfrancesco, Chiara Santanatoglia, Enrica Cappellozza, Marta Suarez Cubero, Mario Pavez-Giani, Oleh Bakumenko, David Meierhofer, Alan Foley, Susanne Morales-Gonzalez, Isabella Tolle, Diran Herebian, Daniele Bonesso, Ildiko Szabo, Giulia Cecchetto, Sakurako Wong, Monica Moresco, Alessandra Maresca, Ilaria Decimo, Merel J.W. Adjobo-Hermans, Burkhard Kleuser, Lukas Cyganek,  Chris M\u00fchlhausen, Lars Schlotawa,  Valeria Tiranti, Andrea Rossi, Ertan Mayatepek,  Chiara La Morgia, Valerio Carelli, Thomas Klopstock, Felix Distelmaier, Ghanim Ullah,  Stefan Jakobs, Nikolaus Rajewsky, Christine R. Rose, Spyros Petrakis, Frank Edenhofer, Werner Koopmann, Dario Brunetti, Pawel Lisowski, Anu Suomalainen, Antonio del Sol, Emanuela Bottani, Ole Pless,  Markus Schuelke,  Alessandro Prigione. Medrxiv 2025  ","url_pubblicazione":"https:\/\/doi.org\/10.1101\/2025.05.15.25325571"},"_links":{"self":[{"href":"https:\/\/emanuelabottanilab.it\/en\/wp-json\/wp\/v2\/pubblicazioni\/1105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/emanuelabottanilab.it\/en\/wp-json\/wp\/v2\/pubblicazioni"}],"about":[{"href":"https:\/\/emanuelabottanilab.it\/en\/wp-json\/wp\/v2\/types\/pubblicazioni"}],"wp:attachment":[{"href":"https:\/\/emanuelabottanilab.it\/en\/wp-json\/wp\/v2\/media?parent=1105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}