{"id":1144,"date":"2025-10-23T22:05:26","date_gmt":"2025-10-23T20:05:26","guid":{"rendered":"https:\/\/emanuelabottanilab.it\/team\/chiara-santanatoglia\/"},"modified":"2025-11-05T12:30:34","modified_gmt":"2025-11-05T11:30:34","slug":"chiara-santanatoglia","status":"publish","type":"team","link":"https:\/\/emanuelabottanilab.it\/en\/team-member\/chiara-santanatoglia\/","title":{"rendered":"Chiara Santanatoglia, M.Sc."},"featured_media":1145,"parent":0,"template":"","meta":{"_gspb_post_css":""},"class_list":["post-1144","team","type-team","status-publish","has-post-thumbnail","hentry"],"blocksy_meta":[],"yoast_head":"\nChiara Santanatoglia, M.Sc. - Emanuela Bottani Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/emanuelabottanilab.it\/en\/team-member\/chiara-santanatoglia\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chiara Santanatoglia, M.Sc. - 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She then completed an MSc in <em>Molecular and Medical Biotechnology<\/em> at the University of Verona in 2022, conducting her thesis under the supervision of Dr. Emanuela Bottani. Her research focused on T3-mediated transcriptional and metabolic regulation during the development of murine cerebral organoids.<\/span><span data-ccp-props=\"{"134233117":true,"134233118":true,"201341983":0,"335551550":6,"335551620":6,"335559740":240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Chiara joined the Bottani Lab as a Research Fellow in November 2022, focusing on the investigation of potential drug treatments for various mitochondrial diseases, particularly maternally inherited Leigh syndrome (MILS), using patient-derived iPSC models differentiated into neuroprogenitor cells (NPCs). During her time in the Bottani Lab, she developed a strong interest and enthusiasm for genetic diseases and contributed to several research activities, including a collaborative study on <\/span><span data-contrast=\"auto\"><em>in utero<\/em> gene therapy for genetic disorders.<\/span><\/p>\n<p><span data-contrast=\"auto\">Since February 2025, Chiara has been a <em>Senior Research Fellow<\/em> at the Unit of Medical Genetics and Neurogenetics, Neurological Institute Carlo Besta in Milan, under the supervision of Dr. Valeria Tiranti. Her current research focuses on identifying therapeutic strategies for Leber\u2019s Hereditary Optic Neuropathy (LHON), using in vitro models such as iPSC-derived NPCs and neurons. She also explores mitochondrial transplantation via extracellular vesicles (EVs).<\/span><span data-ccp-props=\"{"134233117":true,"134233118":true,"201341983":0,"335551550":6,"335551620":6,"335559740":240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">We are enthusiastic about Chiara\u2019s new professional journey and sincerely wish her all the best in her research and future endeavours.<\/span><span data-ccp-props=\"{"201341983":0,"335551550":6,"335551620":6,"335559740":276}\">\u00a0<\/span><\/p>\n","ordinamento_team_ad_es_1_2_3":"9"},"_links":{"self":[{"href":"https:\/\/emanuelabottanilab.it\/en\/wp-json\/wp\/v2\/team\/1144","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/emanuelabottanilab.it\/en\/wp-json\/wp\/v2\/team"}],"about":[{"href":"https:\/\/emanuelabottanilab.it\/en\/wp-json\/wp\/v2\/types\/team"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/emanuelabottanilab.it\/en\/wp-json\/wp\/v2\/media\/1145"}],"wp:attachment":[{"href":"https:\/\/emanuelabottanilab.it\/en\/wp-json\/wp\/v2\/media?parent=1144"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}